The immunomodulatory potential of Commiphora gileadensis and Cynanchum radians extracts in mice

Abstract

We aimed to investigate the effect of Commiphora gileadensis and Cynanchum radians extracts on T lymphocyte subsets. Fifty mice were divided into five groups: control group, C. gileadensis acetone-treated group, C. gileadensis sap-treated group, C. radians acetone-treated group, and C. radians methanolic-treated group. Blood was collected for flow cytometric analysis to measure various lymphocyte populations. A one-way ANOVA test was chosen to compare between-group differences. Data shows that there was a significant decrease in the number of total lymphocytes, CD3⁺, CD4⁺, and CD8+ cells in all mice treated with all extracts compared with controls. In addition, the CD4/CD8 ratio was significantly higher in mice treated with C. gileadensis acetone extract. Furthermore, there was an elevation of CD4⁺/CD25⁺ and CD8⁺/CD25⁺ cells in all groups treated with all extracts as compared with the control group. This study concluded that C. gileadensis and C. radians have immunomodulatory properties.